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Journal article

Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.

Abstract:

BACKGROUND: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. METHODS AND FINDINGS: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 parti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0029849

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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National Health and Medical Research Council Clinical Trials Centre (CTC), Australia More from this funder
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), UK More from this funder
Medical Research Council More from this funder
Cancer Research UK More from this funder
European Community Biomed Programme More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
7
Issue:
1
Article number:
e29849
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
313034
Language:
English
Keywords:
Pubs id:
pubs:313034
UUID:
uuid:f5f58e2a-2ee6-43cf-a422-6e4000d888a1
Local pid:
pubs:313034
Deposit date:
2012-12-19

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