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Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling task

Abstract:
Rationale Adding reward-concurrent cues to a rat gambling task (rGT) increases risky choice. This cued version of the task may reflect an “addiction-like” cognitive process, more similar to human gambling than the uncued task. Serotonergic drugs that target 5-HT2 receptors alter mechanisms linked to impulse control. However, relatively little is known regarding the impact of such agents on either risky decision making, or the ability of conditioned stimuli to bias the choice ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00213-017-4696-4

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0001-9774-3692
More by this author
Role:
Author
ORCID:
0000-0002-1140-2422
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
University College
Role:
Author
ORCID:
0000-0001-7434-9713
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Psychopharmacology Journal website
Volume:
234
Issue:
20
Pages:
3091-3104
Publication date:
2017-07-21
Acceptance date:
2017-07-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Pmid:
28733811
Source identifiers:
709562
Language:
English
Keywords:
Pubs id:
pubs:709562
UUID:
uuid:f638a029-7b3c-4037-a3c2-95b4713a8326
Local pid:
pubs:709562
Deposit date:
2018-09-20

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