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Thesis

The role of the hypoxia-inducible pathway in metabolism and cardiopulmonary physiology

Abstract:

The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of transcription factors in metabolism and cardiopulmonary physiology. Specifically, the effects of HIF on ventilatory control, carotid body morphology, and cardiac metabolism and function were studied using a murine model of a genetic disorder of oxygen sensing known as Chuvash polycythaemia.

HIF coordinates oxygen-regulated gene expression throughout all organ systems, thereby orchestrat...

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Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
University College
Role:
Author
More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
More from this funder
Funding agency for:
Slingo, M
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:f674808e-6731-49e9-b838-1032875a2ced
Local pid:
ora:9080
Deposit date:
2014-10-14

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