The role of the hypoxia-inducible pathway in metabolism and cardiopulmonary physiology
The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of transcription factors in metabolism and cardiopulmonary physiology. Specifically, the effects of HIF on ventilatory control, carotid body morphology, and cardiac metabolism and function were studied using a murine model of a genetic disorder of oxygen sensing known as Chuvash polycythaemia.
HIF coordinates oxygen-regulated gene expression throughout all organ systems, thereby orchestrat...Expand abstract
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- Oxford University, UK
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- Mary Slingo
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