Journal article
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
- Abstract:
-
Aims Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations between GCH1 variants and increased heart rat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1093/cvr/cvs005
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Authors
Funding
Medical Research Council
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British Heart Foundation
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular Research Journal website
- Volume:
- 31
- Issue:
- 4
- Pages:
- 78-78
- Publication date:
- 2012-01-11
- Acceptance date:
- 2012-01-06
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0195-668X
- Source identifiers:
-
132198
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:132198
- UUID:
-
uuid:f68a797a-e8ef-4f87-895b-8df9ca943e93
- Local pid:
- pubs:132198
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Adlam et al
- Copyright date:
- 2012
- Rights statement:
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Authors 2012.
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