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Journal article

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

Abstract:

Aims Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations between GCH1 variants and increased heart rat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvs005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Medical Research Council More from this funder
British Heart Foundation More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
31
Issue:
4
Pages:
78-78
Publication date:
2012-01-11
Acceptance date:
2012-01-06
DOI:
EISSN:
1755-3245
ISSN:
0195-668X
Source identifiers:
132198
Language:
English
Keywords:
Pubs id:
pubs:132198
UUID:
uuid:f68a797a-e8ef-4f87-895b-8df9ca943e93
Local pid:
pubs:132198
Deposit date:
2012-12-19

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