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Journal article

Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades.

Abstract:

Knowledge of immune mechanisms responsible for the cross-protection between highly divergent viruses such as human immunodeficiency virus type 1 (HIV-1) and HIV-2 may contribute to an understanding of whether virus variability may be overcome in the design of vaccine candidates which are broadly protective across the HIV subtypes. We demonstrate that despite the significant difference in virus amino acid sequence, the majority of HIV-2-infected individuals with different HLA molecules possess...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
72
Issue:
3
Pages:
2439-2448
Publication date:
1998-03-01
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
176660

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