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Heparan sulfate organizes neuronal synapses through neurexin partnerships

Abstract:

Synapses are fundamental units of communication in the brain. The prototypical synapse-organizing complex neurexin-neuroligin mediates synapse development and function and is central to a shared genetic risk pathway in autism and schizophrenia. Neurexin’s role in synapse development is thought to be mediated purely by its protein domains, but we reveal a requirement for a rare glycan modification. Mice lacking heparan sulfate (HS) on neurexin-1 show reduced survival, as well as structural and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2018.07.002

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Funding agency for:
Aricescu, AR
Grant:
MC_UP_1201/15
Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
174
Issue:
6
Pages:
1450-1464.e23
Publication date:
2018-08-09
Acceptance date:
2018-06-29
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
30100184
Source identifiers:
907531
Language:
English
Keywords:
Pubs id:
pubs:907531
UUID:
uuid:f71525da-36fc-4fc9-8649-dff6c33a610f
Local pid:
pubs:907531
Deposit date:
2018-09-02

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