Journal article
Heparan sulfate organizes neuronal synapses through neurexin partnerships
- Abstract:
-
Synapses are fundamental units of communication in the brain. The prototypical synapse-organizing complex neurexin-neuroligin mediates synapse development and function and is central to a shared genetic risk pathway in autism and schizophrenia. Neurexin’s role in synapse development is thought to be mediated purely by its protein domains, but we reveal a requirement for a rare glycan modification. Mice lacking heparan sulfate (HS) on neurexin-1 show reduced survival, as well as structural and...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 2.5MB)
-
- Publisher copy:
- 10.1016/j.cell.2018.07.002
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Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Aricescu, AR
Grant:
MC_UP_1201/15
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 174
- Issue:
- 6
- Pages:
- 1450-1464.e23
- Publication date:
- 2018-08-09
- Acceptance date:
- 2018-06-29
- DOI:
- EISSN:
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1097-4172
- ISSN:
-
0092-8674
- Pmid:
-
30100184
- Source identifiers:
-
907531
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:907531
- UUID:
-
uuid:f71525da-36fc-4fc9-8649-dff6c33a610f
- Local pid:
- pubs:907531
- Deposit date:
- 2018-09-02
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2018
- Notes:
- © 2018 Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.cell.2018.07.002
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