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Journal article

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.

Abstract:

Background

Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomaliesincluding cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia, Cardiac defects, Tracheoesophageal fistula and/or Esophageal atresia, R...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12861-017-0148-y

Authors


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Institution:
University of Oxford
Oxford college:
New College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Developmental Biology Journal website
Volume:
17
Issue:
1
Pages:
6
Publication date:
2017-04-01
Acceptance date:
2017-04-17
DOI:
ISSN:
1471-213X
Language:
English
Keywords:
Pubs id:
pubs:692368
UUID:
uuid:f797bee9-e00c-43fd-a4c0-ae0a8bb131e2
Local pid:
pubs:692368
Deposit date:
2017-07-10

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