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A prenylated dsRNA sensor protects against severe COVID-19

Abstract:

INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to invading pathogens. By initiating a signaling cascade that stimulates the expression of hundreds of genes, IFNs create an antiviral state in host cells. Because IFNs heavily influence COVID-19 outcomes, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication can be inhibited by the antiviral state, it is important to understand how the individual antiviral effectors encoded by IFN-stimu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.abj3624

Authors


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Role:
Author
ORCID:
0000-0001-5470-1505
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Role:
Author
ORCID:
0000-0001-5014-9522
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Role:
Author
ORCID:
0000-0003-4202-6682
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Role:
Author
ORCID:
0000-0002-4834-8888
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Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Oxford college:
Keble College
Role:
Contributor
ORCID:
0000-0002-4502-2209
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Strategic
Oxford college:
Worcester College
Role:
Contributor
ORCID:
0000-0003-3598-7784
Oxfordshire Health Service Research Comm More from this funder
Healthcare Infection Society More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
374
Issue:
6567
Article number:
eabj3624
Publication date:
2021-09-28
Acceptance date:
2021-09-23
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
34581622
Language:
English
Keywords:
Pubs id:
1196789
Local pid:
pubs:1196789
Deposit date:
2021-11-28

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