Journal article
A prenylated dsRNA sensor protects against severe COVID-19
- Abstract:
-
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to invading pathogens. By initiating a signaling cascade that stimulates the expression of hundreds of genes, IFNs create an antiviral state in host cells. Because IFNs heavily influence COVID-19 outcomes, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication can be inhibited by the antiviral state, it is important to understand how the individual antiviral effectors encoded by IFN-stimu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 2.7MB)
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- Publisher copy:
- 10.1126/science.abj3624
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Authors
Contributors
+ Mentzer, AJ
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Oxford college:
Keble College
Role:
Contributor
ORCID:
0000-0002-4502-2209
+ ISARIC4C Investigators
Role:
Contributor
+ Lee, J
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Contributor
+ Angus, B
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Strategic
Oxford college:
Worcester College
Role:
Contributor
ORCID:
0000-0003-3598-7784
Funding
Oxfordshire Health Service Research Comm
More from this funder
Healthcare Infection Society
More from this funder
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 374
- Issue:
- 6567
- Article number:
- eabj3624
- Publication date:
- 2021-09-28
- Acceptance date:
- 2021-09-23
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Pmid:
-
34581622
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1196789
- Local pid:
- pubs:1196789
- Deposit date:
- 2021-11-28
Terms of use
- Copyright holder:
- Wickenhagen et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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