Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

Journal article

Strong CD4(+) and CD8(+) T cell responses are considered important immune components for controlling HIV infection, and their priming may be central to an effective HIV vaccine. We describe in this study an approach by which multiple CD4(+) and CD8(+) T cell epitopes are processed and presented from an exogenously added HIV-1 Gag-p24 peptide of 32 aa complexed to heat shock protein (HSP) gp96. CD8(+) T cell recognition of the HSP/peptide complex, but not the peptide alone, was inhibited by br...

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Authors: SenGupta, D; Norris, P; Suscovich, T; Hassan-Zahraee, M; Moffett, H

• Journal: Journal of Immunology
• Volume: 173
• Issue: 3
• Pages: 1987-1993
• Publication date: 2004-08-01
• DOI: 10.4049/jimmunol.173.3.1987
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Humans; Cell Line, Transformed; Antigens, Neoplasm; Amino Acid Sequence; HIV Core Protein p24; HLA-DQ Antigens; HIV Antigens; Antigen Presentation; B-Lymphocytes; HIV-1; Histocompatibility Antigens Class I; Peptide Fragments; Epitopes, B-Lymphocyte; Histocompatibility Antigens Class II; Antigens, CD; Low Density Lipoprotein Receptor-Related Protein-1; Molecular Sequence Data; CD8-Positive T-Lymphocytes; Herpesvirus 4, Human; Dendritic Cells; Epitopes, T-Lymphocyte; AIDS Vaccines; Brefeldin A; HLA-B Antigens