Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.

Journal article

Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T-lymphocyte epitopes. Here we combine sequence data and functional studies of CD8 T-cell responses to demonstrate that allele-specific immune pressures also select for mutations flanking CD8 epitopes that impair antigen processing. In persons expres...

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Authors: Allen, T; Altfeld, M; Yu, X; O'Sullivan, K; Lichterfeld, M

• Publication status: Published
• Journal: Journal of virology
• Volume: 78
• Issue: 13
• Pages: 7069-7078
• Publication date: 2004-07-01
• DOI: 10.1128/jvi.78.13.7069-7078.2004
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Humans; HIV Infections; Amino Acid Substitution; Amino Acid Sequence; Selection, Genetic; T-Lymphocytes, Cytotoxic; HIV Antigens; Antigen Presentation; Gene Products, gag; HIV-1; gag Gene Products, Human Immunodeficiency Virus; Molecular Sequence Data; Immunodominant Epitopes; Evolution, Molecular; Viral Proteins; Epitopes, T-Lymphocyte; HLA-A3 Antigen