Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1.

Journal article

The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful stimuli including ischemia. We hypothesized that TRPV1 is expressed in the arterioles and is involved in the regulation of microvascular tone. We found that TRPV1 stimulation by capsaicin (intra-arterial administration) of the isolated, perfused right hind limb of the rat increased vascular resistance (by 98 +/- 21 mm Hg at 10 mug) in ass...

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Authors: Kark, T; Bagi, Z; Lizanecz, E; Pásztor, E; Erdei, N

• Publication status: Published
• Journal: Molecular pharmacology
• Volume: 73
• Issue: 5
• Pages: 1405-1412
• Publication date: 2008-05-01
• DOI: 10.1124/mol.107.043323
• EISSN: 1521-0111
• ISSN: 0026-895X
• Language: English
• Keywords: TRPV Cation Channels; Organ Specificity; Perfusion; Muscle Denervation; Rats; Arterioles; Ion Channel Gating; Male; RNA, Messenger; Hindlimb; Muscle, Smooth; Models, Biological; Neurons; Rats, Wistar; Muscle, Skeletal; Gene Expression Regulation; Skin; Animals