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Thesis

Malaria pre-erythrocytic stage vaccines: targeting antigen combinations

Abstract:

Consistent efficacy in human clinical trials has been achieved by two leading malaria vaccine candidates encoding either the P. falciparum circumsporozoite (CSP) or thrombospondin-related adhesion (TRAP) proteins. However, protection in humans relies on high antibody (Ab) titers or potent T cells, respectively, when these antigens are used individually. Therefore, a concurrent induction of both anti-CSP antibodies and TRAP-specific T cells may further improve the protective effica...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Hill's Group
Oxford college:
Hertford College
Role:
Author

Contributors

Division:
HUMS
Department:
Medieval & Modern Languages Faculty
Role:
Supervisor
Division:
HUMS
Department:
Medieval & Modern Languages Faculty
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:f96234df-74fa-4461-ba2e-a3cc4f8abfa0
Local pid:
ora:7015
Deposit date:
2013-07-16

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