SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.

Journal article

Phagocytic and pathogen sensing receptors are responsible for particle uptake and inflammation. It is unclear how these receptors' systems influence each other's function to shape an innate response. The class-A scavenger receptors SR-A (scavenger receptor A) and MARCO (macrophage receptor with collagenous structure) are 2 well-characterized phagocytic receptors that are unable to initiate inflammatory responses by themselves, yet are implicated in the pathogenesis of various inflammatory dis...

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Authors: Mukhopadhyay, S; Varin, A; Chen, Y; Liu, B; Tryggvason, K

• Publication status: Published
• Journal: Blood
• Volume: 117
• Issue: 4
• Pages: 1319-1328
• Publication date: 2011-01-01
• DOI: 10.1182/blood-2010-03-276733
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Toll-Like Receptors; Cells, Cultured; Peritonitis; Nod Signaling Adaptor Proteins; Mice; Animals; Scavenger Receptors, Class A; Mice, Knockout; Ligands; Protein Transport; Toll-Like Receptor 4; Cytokines; Cell Membrane; Antigen Presentation; Mice, Inbred C57BL; Receptors, Immunologic