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Mom’s diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring

Abstract:

Compelling evidence links enteric microbes to brain function and behavior. Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents. Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbi.2020.09.034

Authors


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Role:
Author
ORCID:
0000-0001-8781-7459
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0002-8580-2023
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-8432-8622
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Publisher:
Elsevier Publisher's website
Journal:
Brain, Behavior, and Immunity Journal website
Volume:
91
Pages:
230-244
Publication date:
2020-10-05
Acceptance date:
2020-09-30
DOI:
EISSN:
1090-2139
ISSN:
0889-1591
Pmid:
33031920
Language:
English
Keywords:
Pubs id:
1136788
Local pid:
pubs:1136788
Deposit date:
2021-08-09

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