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Thesis

Characterising the cardiac effects of dysregulated propionate metabolism using a mouse model of propionic acidaemia

Abstract:

Propionate is a naturally-occurring monocarboxylate short-chain fatty acid in humans derived from the mitochondrial metabolism of multiple substrates. There is evidence for dysregulated propionate metabolism (and hence its accumulation), in common metabolic disorders, such as diabetes and obesity. However, the most extreme accumulation of propionate occurs in the inherited metabolic disease, propionic acidaemia (PA). Despite its rarity, PA is one of the commonest organic acidaemias. PA res...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Programme:
British Heart Foundation 4-Year Non-Clinical PhD Studentship
Grant:
FS/16/59/32735
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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