Thesis
Characterising the cardiac effects of dysregulated propionate metabolism using a mouse model of propionic acidaemia
- Abstract:
-
Propionate is a naturally-occurring monocarboxylate short-chain fatty acid in humans derived from the mitochondrial metabolism of multiple substrates. There is evidence for dysregulated propionate metabolism (and hence its accumulation), in common metabolic disorders, such as diabetes and obesity. However, the most extreme accumulation of propionate occurs in the inherited metabolic disease, propionic acidaemia (PA). Despite its rarity, PA is one of the commonest organic acidaemias. PA res...
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Funding
+ British Heart Foundation
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Programme:
British Heart Foundation 4-Year Non-Clinical PhD Studentship
Grant:
FS/16/59/32735
Funder identifier:
http://dx.doi.org/10.13039/501100000274
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-08-24
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Terms of use
- Copyright holder:
- Park, KC
- Copyright date:
- 2021
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