Journal article
Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes
- Abstract:
-
AIM: Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic variation in a large number of non-sarcomeric genes has also been implicated in HCM but not formally assessed. Here we used very large case and control cohorts to determine the extent to which variation in non-sarcomeric genes contributes to HCM. METHODS AND RESULTS: We sequenced known and putative HCM genes in a new large prospective HCM cohort (n = 804) and...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ British Heart Foundation Centre of Research Excellence, Oxford
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Grant:
RE/13/1/30181
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- European Heart Journal Journal website
- Volume:
- 38
- Issue:
- 46
- Pages:
- 3461–3468
- Publication date:
- 2017-01-11
- Acceptance date:
- 2016-11-24
- DOI:
- EISSN:
-
1522-9645
- ISSN:
-
0195-668X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:671983
- UUID:
-
uuid:fb21cce6-cbf7-493d-8560-18a4ae5e928a
- Local pid:
- pubs:671983
- Source identifiers:
-
671983
- Deposit date:
- 2017-02-13
Terms of use
- Copyright holder:
- Walsh et al
- Copyright date:
- 2017
- Notes:
- Copyright © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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