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Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Abstract:

Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T (Treg) cell output in preeclamptic pregnancies, which persists up to 4 years of age in human offspring. In germ-free mice, fetal thymic CD4+ T cell and Treg cell development are compro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-10703-1

Authors


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Role:
Author
ORCID:
0000-0002-0104-2072
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Role:
Author
ORCID:
0000-0001-5371-8778
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Contributors

Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women's and Reproductive Health
Department:
Oxford, MSD, Womens & Reproductive Health
Role:
Contributor
Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Issue:
1
Article number:
3031
Publication date:
2019-07-10
Acceptance date:
2019-05-23
DOI:
EISSN:
2041-1723
Pmid:
31292453
Source identifiers:
1035719

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