Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia.

Journal article

Changes in protein kinase C (PKC) were compared in primary cortical neurons exposed to glutamate and in the CA-1 hippocampal region of rats subjected to transient cerebral ischaemia. After a 15-min exposure of cortical neurons to excitotoxic levels of glutamate, a 50-60% loss of membrane PKC activity but only about a 20% loss in the amount of enzyme was observed, suggesting that in addition to enzyme loss other mechanisms also contributed to the overall loss of membrane PKC activity. Glutamat...

Expand abstract

Authors: Chakravarthy, B; Wang, J; Tremblay, R; Atkinson, T; Wang, F

• Publication status: Published
• Journal: Cellular signalling
• Volume: 10
• Issue: 4
• Pages: 291-295
• Publication date: 1998-04-01
• DOI: 10.1016/s0898-6568(97)00131-9
• EISSN: 1873-3913
• ISSN: 0898-6568
• Language: English
• Keywords: Animals; Rats, Wistar; Rats; Male; Excitatory Amino Acid Agonists; Cerebral Cortex; Glutamic Acid; Cells, Cultured; Enzyme Induction; Neurons; Brain Ischemia; Protein Kinase C