Deciphering antigen recognition by lymphocyte receptors: Insights from T-cell receptors and antibodies

Thesis

The adaptive immune system is composed of specialised cells that detect and respond to foreign pathogens. T cells and B cells, the main coordinators of this immune response, present lymphocyte antigen receptors on their cell surface that can bind to antigens of foreign pathogens. Lymphocyte antigen receptors encompasses the T-cell receptor (TCR) on the surface of T cells, which bind peptide antigens presented by MHC complexes (peptide-MHC) on the surface of cells. The second type of antigen r...

Expand abstract

Authors: Huhn, AG

• DOI: 10.5287/ora-y5yazvpwr
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: T-cell receptors; antibodies; antigen recognition
• Subjects: Molecular biology; Biophysics; Immunology