Neuroprotection and neurogenesis: modulation of cornus ammonis 1 neuronal survival after transient forebrain ischemia by prior fimbria-fornix deafferentation.

Journal article

Severe transient forebrain ischemia causes selective neuronal death in the hippocampal cornus ammonis 1 region. We tested the hypothesis that fimbria-fornix deafferentation can provide long-term protection to cornus ammonis 1 neurons and modulate neurogenesis following ischemia. Fimbria-fornix lesion or sham-fimbria-fornix lesion was performed on Wistar rats 13 days prior to 10 min forebrain ischemia or sham ischemia. Temperature was regulated and rats survived for 7, 14 or 28 days. Immunoflu...

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Authors: Zhao, Z; Sun, P; Chauhan, N; Kaur, J; Hill, MD

• Publication status: Published
• Journal: Neuroscience
• Volume: 140
• Issue: 1
• Pages: 219-226
• Publication date: 2006-06-01
• DOI: 10.1016/j.neuroscience.2006.02.011
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Analysis of Variance; Microscopy, Confocal; Cell Count; Neurons; Cell Proliferation; Immunohistochemistry; Phosphopyruvate Hydratase; Rats; Organogenesis; Bromodeoxyuridine; Hippocampus; Disease Models, Animal; Ischemic Attack, Transient; Time Factors; Cell Survival; Animals; Fornix, Brain; Male; Rats, Wistar