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Systems-level analysis of the mitotic entry switch

Abstract:

Entry into mitosis in eukaryotes depends on the activation of the Cyclin-dependent kinase 1 (Cdk1), which phosphorylates many mitotic protein substrates. Activation of Cdk1 requires formation of a complex with Cyclin B (CycB), which gradually rises in concentration during interphase. However, in most organisms Cdk1 activation is not gradual but switch-like, because phosphorylation of the Cdk1-CycB complex by the Wee1 kinase normally keeps Cdk1-CycB inactive during interphase. Mitotic entry is...

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Oxford college:
St John's College
Role:
Author
More by this author
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author

Contributors

Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:fca26251-2c75-4c3e-91b1-ea9cb1674b43
Local pid:
ora:6582
Deposit date:
2012-11-30

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