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Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies

Abstract:

Offspring of hypertensive pregnancies are more likely to have microvascular rarefaction and increased blood pressure in later life. We tested the hypothesis that maternal angiogenic profile during a hypertensive pregnancy is associated with fetal vasculogenic capacity and abnormal postnatal microvascular remodeling. Infants (n=255) born after either hypertensive or normotensive pregnancies were recruited for quantification of postnatal dermal microvascular structure at birth and 3 months of a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/HYPERTENSIONAHA.116.07586

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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More from this funder
Funding agency for:
Channon, K
Grant:
CH/16/1/32013
More from this funder
Funding agency for:
Leeson, P
Grant:
FS/11/65/28865
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
68
Issue:
3
Pages:
749-759
Publication date:
2016-07-25
Acceptance date:
2016-06-27
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Language:
English
Keywords:
Pubs id:
pubs:636254
UUID:
uuid:fca9f248-39e0-402b-8680-8834b728aa63
Local pid:
pubs:636254
Deposit date:
2016-08-23

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