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Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

Abstract:

Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors. Here we use whole-genome sequencing to identify somatic mutations and chromosomal changes in 14 bladder cancers of different grades and stages. As well as detecting the known bladder cancer driver mutations, we report the identification of recurrent protein-inactivating mutations in CDKN1A and FAT1. The former ar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms4756

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Institution:
University of Oxford
Research group:
Bioinformatics Group
Role:
Author
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Institution:
University of Oxford
Research group:
Botnar Research Centre
Role:
Author
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Institution:
University of Oxford
Research group:
Oxford Cancer Research Centre
Role:
Author
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Institution:
University of Oxford
Research group:
Oxford Cancer Research Centre
Role:
Author
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Funding agency for:
Cazier, J
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Funding agency for:
Tomlinson, I
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Funding agency for:
Kiltie, A
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Funding agency for:
Hamdy, F
Oxford Partnership Comprehensive Biomedical Research Centre More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
5
Article number:
3756
Publication date:
2014-01-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Source identifiers:
463055
Language:
English
Keywords:
Pubs id:
pubs:463055
UUID:
uuid:fcce37ff-a4f6-43b2-ad10-58f72575e2cd
Local pid:
pubs:463055
Deposit date:
2014-06-04

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