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Journal article

An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels

Abstract:

Inositol polyphosphates are ubiquitous molecular signals in metazoans, as are their pyrophosphorylated derivatives that bear a so-called ‘high-energy’ phosphoanhydride bond. A structural rationale is provided for the ability of Arabidopsis inositol tris/tetrakisphosphate kinase 1 to discriminate between symmetric and enantiomeric substrates in the production of diverse symmetric and asymmetric myo-inositol phosphate and diphospho-myo-inositol phosphate (inositol pyrophosphate) products. Simpl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/BCJ20200423

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
ORCID:
0000-0003-3255-9135
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Publisher:
Portland Press Publisher's website
Journal:
Biochemical Journal Journal website
Volume:
477
Issue:
14
Pages:
2621-2638
Publication date:
2020-07-24
Acceptance date:
2020-07-06
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
1116650
Local pid:
pubs:1116650
Deposit date:
2020-07-06

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