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Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations

Abstract:

BACKGROUND: Localising regulatory variants that control gene expression is a challenge for genome research. Several studies have recently identified non-coding polymorphisms associated with inter-individual differences in gene expression. These approaches rely on the identification of signals of association against a background of variation due to other genetic and environmental factors. A complementary approach is to use an Allele-Specific Expression (ASE) assay, which is more robust to the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0004105

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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Bill and Melinda Gates Foundation More from this funder
Wellcome Trust More from this funder
Fundacao para a Ciencia e Tecnologia More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
3
Issue:
12
Article number:
e4105
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
34540
Language:
English
Keywords:
Pubs id:
pubs:34540
UUID:
uuid:fe97d2bd-2b8f-4f32-aa71-6a842218d4b2
Local pid:
pubs:34540
Deposit date:
2012-12-19

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