Thesis
Establishment and maintenance of the DNA methylation pattern in the human alpha-globin cluster
- Abstract:
-
DNA methylation is an epigenetic modification that plays an important role in development and differentiation. The patterns of DNA methylation are largely established in early embryogenesis and maintained during development. Abnormal DNA methylation patterns have been associated with many human diseases, including cancer. Despite its importance, little is currently known about the mechanisms that determine DNA methylation patterns throughout the genome. To shed light on the molecular mecha...
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Authors
Contributors
+ Gibbons, R
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
+ Higgs, D
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:fecf70d2-4845-4f42-b890-c163a1020eec
- Local pid:
- ora:11321
- Deposit date:
- 2015-04-30
Terms of use
- Copyright holder:
- Ricarda Gaentzsch
- Copyright date:
- 2013
- Notes:
- This thesis is currently not available on ORA.
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