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Thesis

Characterisation of the transcriptomes of Leishmania mexicana promastigotes and amastigotes

Abstract:

Leishmania spp. undergo substantial adaptations from being promastigotes, found in sandflies, to being amastigotes, residing in parasitophorous vacuoles within mammalian macrophages. In the past, microarray studies have sought to elucidate these adaptations using axenic amastigote systems or amastigotes purified from host-cells, raising the question whether the observed transcriptomic signatures were a true reflection of intracellular amastigotes. Moreover, with ever-improving gen...

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Institution:
University of Oxford
Division:
MSD
Research group:
Dr. Eva Gluenz & Prof. Keith Gull
Oxford college:
University College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
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Funding agency for:
Fiebig, M
Grant:
092870/Z/10/Z
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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