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In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control

Abstract:

Background: Angiotensin I converting enzyme 2 (ACE2) is a receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and differences in its expression may affect susceptibility to infection.
Methods: We performed a genome-wide expression quantitative trait loci (eQTL) analysis using hepatitis C virus-infected liver tissue from 190 individuals.
Results: We discovered that polymorphism in a type III interferon gen... Expand abstract
Publication status:
Under review
Peer review status:
Under review

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Publisher copy:
10.12688/wellcomeopenres.16559.1

Authors


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Role:
Author
ORCID:
0000-0003-2790-8353
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-3297-2483
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Contributors

Role:
Contributor
Role:
Contributor
Wellcome Trust More from this funder
Publisher:
F1000 Research Ltd
Journal:
Wellcome Open Research Journal website
Volume:
6
Article number:
47
Publication date:
2021-03-03
DOI:
EISSN:
2398-502X
Language:
English
Keywords:
Pubs id:
1167517
Local pid:
pubs:1167517
Deposit date:
2021-11-19

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