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Impact of moderate alcohol consumption on brain iron and cognition: observational and genetic analyses

Abstract:

Brain iron deposition has been linked to several neurodegenerative conditions and reported in alcohol dependence. Whether iron accumulation occurs in moderate drinkers is unknown. Our objectives were to investigate causal relationships between alcohol consumption and brain iron levels and to examine whether higher brain iron represents a potential pathway to alcohol-related cognitive deficits.

Multi-organ susceptibility-weighted magnetic resonance imaging was used to ascertain iron...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2022.02.07.22270583

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-8408-0372
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Role:
Author
ORCID:
0000-0001-9402-1563
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Linacre College; Linacre College; Linacre College; LINACRE COLLEGE
Role:
Author
ORCID:
0000-0002-5190-7038
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Role:
Author
ORCID:
0000-0001-5365-8760
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Host title:
Cold Spring Harbor Laboratory
Publication date:
2022-02-07
DOI:
Language:
English
Keywords:
Pubs id:
1238684
Local pid:
pubs:1238684
Deposit date:
2022-02-09

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